II. Indications
III. Pharmacokinetics
- Half life: 6 hours
- Hepatic metabolism
IV. Dosing: Parkinsonism
- Immediate Release start 0.25 mg three times daily (may increase by 0.25 mg/week up to 24 mg/day)
- Extended Release start 2 mg daily (may increase by 2 mg/week up to 24 mg/day)
V. Dosing: Restless Leg Syndrome
- Start: Requip 0.25 mg orally taken 2-3 hours before bedtime
- Interval for increasing dose: 3-7 days
- Titrating dose: Increase at set interval as above by one tablet if ineffective at current dose
- Start at 0.25 mg one tablet nightly for set interval in days
- Increase to two tablets (0.50 mg) nightly for set interval if ineffective at 0.25 mg
- Increase to three tablets (0.75 mg) nightly for set interval if ineffective at 0.50 mg
- Maximum dose: 6 tablets (1.5 mg) taken at bedtime
- Stopping: No titration needed
VI. Adverse Effects (similar to Mirapex)
- Nausea (common)
- Drowsiness (Limited to higher dosages)
- May be sudden, severe without warning
- May occur up to one year after starting Mirapex
- Has resulted in falling asleep while driving
- Augmentation of Restless Leg Symptoms
- Occurs in 25% of RLS patients on longterm therapy
- May progress in severity, and involve arms, trunk
- Often better if dose timing changed to earlier in day
- May be worse if dose increased
- Other uncommon adverse effects (rare at low dose)
- Hallucinations
- Pathologic Gambling (related to Dopamine receptor agonist activity, D3)
- Orthostatic Hypotension
- Hypersexuality
Images: Related links to external sites (from Bing)
Related Studies
| ropinirole (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ROPINIROLE HCL 0.25 MG TABLET | Generic | $0.09 each |
| ROPINIROLE HCL 0.5 MG TABLET | Generic | $0.07 each |
| ROPINIROLE HCL 1 MG TABLET | Generic | $0.07 each |
| ROPINIROLE HCL 2 MG TABLET | Generic | $0.09 each |
| ROPINIROLE HCL 3 MG TABLET | Generic | $0.11 each |
| ROPINIROLE HCL 4 MG TABLET | Generic | $0.11 each |
| ROPINIROLE HCL 5 MG TABLET | Generic | $0.13 each |
| ROPINIROLE HCL ER 12 MG TABLET | Generic | $6.06 each |
| ROPINIROLE HCL ER 2 MG TABLET | Generic | $1.15 each |
| ROPINIROLE HCL ER 4 MG TABLET | Generic | $2.82 each |
| ROPINIROLE HCL ER 6 MG TABLET | Generic | $3.72 each |
| ROPINIROLE HCL ER 8 MG TABLET | Generic | $3.71 each |
| requip (on 1/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| REQUIP XL 2 MG TABLET | Generic | $1.15 each |
| REQUIP XL 4 MG TABLET | Generic | $2.82 each |
| REQUIP XL 6 MG TABLET | Generic | $3.72 each |
| REQUIP XL 8 MG TABLET | Generic | $3.71 each |
Ontology: ropinirole (C0244821)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C046649 |
| SnomedCT | 108473005, 372499000 |
| English | 4-(2-(di-n-propylamino)ethyl)-2(3H)-indolone, ropinirol, ropinirole, ropinirole [Chemical/Ingredient], rOPINIRole, ROPINIROLE, Ropinirole, Ropinirole (product), Ropinirole (substance) |
| Spanish | ropinirola (sustancia), ropinirol (sustancia), ropinirola, ropinirol (producto), ropinirol |
Ontology: Requip (C0593342)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C046649 |
| English | Requip, requip, GlaxoSmithKline brand of ropinirole hydrochloride, SmithKline Beecham brand of ropinirole hydrochloride |
