II. Indications
- Adjunctive agent in Refractory Partial-Onset Seizures
- Bipolar Disorder
- Trigeminal Neuralgia
III. Mechanism
- Antiepileptic
- Sodium channel blocker (similar to Carbamazepine and Oxcarbazepine)
IV. Dosing
- Normal Renal Function
- Initial: 400 mg orally once daily for 1 week
- Maintenance: 800 mg orally once daily
- Maximum dose: 1200 mg/day
- Decreased Renal Function to Creatinine Clearance <50 ml/min
- Initial: 200 mg orally once daily for 2 weeks
- Maintenance: 400 mg orally once daily
- Maximum dose: 600 mg/day
V. Adverse Effects
VI. Drug Interactions
- Do not use with other similar Sodium channel blocker agents such as Carbamazepine and Oxcarbazepine
- Hormonal contraceptives
- Eslicarbazepine decreases the contraceptive efficacy
- Use alternative, non-hormonal agents or backup Contraception
VII. Resources
VIII. References
- (2014) Presc Lett 21(11): 65
- Ben-Menachem (2010) Epilepsy Curr 10(1): 7–8 [PubMed]
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