Pharm

Apomorphine

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Apomorphine, Uprima

  • Mechanism
  1. Central acting, Dopaminergic agonist
  • Pharmacokinetics
  1. Onset: 10 minutes
  2. Duration: 30 minutes
  • Dose
  1. Uprima 2 to 6 mg SL
  • Efficacy
  1. Effective in 55 to 60% of men (contrast 32% in Placebo)
  • Adverse Effects (58% of men on 6 mg)
  1. Nausea (39%)
  2. Vomiting (10%)
  3. Dizziness (20%)
  4. Somnolence (11%)
  5. Sweaty (18%)
  6. Hypotension (4%)
  7. Syncope (2%)