Pharm

Thiopental

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Thiopental, Pentothal

  1. Use lower dose if patient volume depleted
  2. Sedative Induction prior to intubation (RSI)
    1. Thiopental 3-5 mg/kg IVP
  • Pharmacokinetics
  1. Onset: 1 min
  2. Duration: 10-30 min
  1. Largely replaced by newer agents for RSI (e.g. Etomidate, Ketamine)
  2. Situations where Thiopental might still be considered in RSI
    1. Status Epilepticus (Fast-acting anti-epileptic)
    2. Increased Intracranial Pressure (Fastest lowering of ICP of any induction agent)
  • Contraindication
  • Adverse Effects
  1. Hypotension
  2. Histamine release
  3. Skin necrosis if infiltrates (highly alkalotic agent with pH 10)