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Purine Synthesis Inhibitor

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Purine Synthesis Inhibitor, Mycophenolate, Cellcept, Mycophenolic acid, MyFortic

  • See Also
  • Indications
  1. Solid Organ Transplant immunosuppression (maintenance prevention of rejection)
  • Adverse Effects
  • Mycophenolate or Mycophenolic acid
  1. See Azathioprine (Imuran)
  2. Bone Marrow suppression
  3. Gastrointestinal adverse effects (e.g. Nausea, Vomiting, Diarrhea, Abdominal Pain)
  • Preparations
  1. Azathioprine (Imuran)
  2. Mycophenolate (Cellcept)
  3. Mycophenolic acid (MyFortic)
  • Drug Interactions
  1. See Cytochrome P-450 3A4
  2. Agents that increase Purine Synthesis Inhibitor concentrations
    1. Linezolid
    2. Valganciclovir (Valcyte) potentiates myelosuppression
    3. Allopurinol (esp. Azathioprine)
  3. Agents that decrease Purine Synthesis Inhibitor concentrations
    1. Rifampin