TNF Inhibitor


TNF Inhibitor, Anti-TNF Agent, Tumor Necrosis Factor Inhibitor, TNF-a blockers, Tumor Necrosis Factor Alpha Inhibitor

  • Preparations
  1. Older xTNF agents included Thalidomide
  2. Modern xTNF agents (in 2016) are primarily monoclonal antibodies
    1. Examples include Infliximab (Remicade), Adalimumab (Humira) and Etanercept (Enbrel)
  • Prevention
  1. Update Vaccinations prior to starting therapy (Live Vaccines may not be used with xTNF agents)
  2. Screen for Tuberculosis and other infections prior to starting xTNF-a agents
  3. Requires regular lab monitoring depending on agent and condition being treated
  4. Skin Cancer Prevention with regular use of Sunscreen and Self Skin Exam
  5. Patients should seek medical evaluation for acute infectious symptoms while on xTNF agents
  • References
  1. (2018) Presc Lett 25(7): 40