Pharm
Etanercept
search
Etanercept
, Enbrel
See Also
Infliximab
(
Remicade
)
Adalimumab
(
Humira
)
Indication
Refractory
Rheumatoid Arthritis
Combined with
Methotrexate
and other
DMARDs
Corticosteroid
sparing in agents
Juvenile Rheumatoid Arthritis
Psoriatic Arthritis
Mechanism
Soluble TNF receptor blocker
Efficacy
Rapid onset and very effective
Arrests XRay progression
Good synergistic effect with
Methotrexate
Adverse Effects
Potential risk of infection
No significant adverse effects
Dosing
Preload
ed vial or syringe: 25 mg SQ twice weekly or 50 mg SC weekly
Cost
Per vial: $150
Per month: $1200
Per year: $14,000
Monitoring
Consider following
Complete Blood Count
References
Bathon (2000) N Engl J Med 343:1586-93 [PubMed]
Weinblatt (1999) N Engl J Med 340: 253-9 [PubMed]
Type your search phrase here