Pharm

Etanercept

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Etanercept, Enbrel

  • See Also
  1. Infliximab (Remicade)
  2. Adalimumab (Humira)
  • Indication
  1. Refractory Rheumatoid Arthritis
    1. Combined with Methotrexate and other DMARDs
    2. Corticosteroid sparing in agents
  2. Juvenile Rheumatoid Arthritis
  3. Psoriatic Arthritis
  • Mechanism
  1. Soluble TNF receptor blocker
  • Efficacy
  1. Rapid onset and very effective
  2. Arrests XRay progression
  3. Good synergistic effect with Methotrexate
  • Adverse Effects
  1. Potential risk of infection
  2. No significant adverse effects
  • Dosing
  1. Preloaded vial or syringe: 25 mg SQ twice weekly or 50 mg SC weekly
  • Cost
  1. Per vial: $150
  2. Per month: $1200
  3. Per year: $14,000
  • Monitoring
  1. Consider following Complete Blood Count
  • References
  1. Bathon (2000) N Engl J Med 343:1586-93 [PubMed]
  2. Weinblatt (1999) N Engl J Med 340: 253-9 [PubMed]