Diffuse

Amyloidosis

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Amyloidosis

  • Pathophysiology
  1. Disturbed endogenous protein metabolism
    1. Primary
    2. Secondary to chronic tissue breakdown
  2. Organ dysfunction arises from deposition
  • Symptoms
  1. Asthenia
  2. Weight loss
  3. Paresthesias
  4. Organ specific symptoms
  • Signs
  1. Organ specific signs
  2. Macroglossia
  3. Hypertension
  4. Lymphadenopathy
  5. Hepatomegaly
  6. Splenomegaly
  7. Purpura
  8. Nephrotic Syndrome
  9. Edema
  10. Joint Pain, Muscle pain
  11. Serous cavity fluid
  • Labs
  1. Biopsy under Congo red or thioflavine-T staining
    1. Exam of Gingiva, Rectum, involved tissues
    2. Green birefringence in polarized light
  2. Serum Immunoglobulins altered