Diffuse
Amyloidosis
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Amyloidosis
Pathophysiology
Disturbed endogenous
Protein Metabolism
Primary
Secondary to chronic tissue breakdown
Organ dysfunction arises from deposition
Symptoms
Asthenia
Weight loss
Paresthesia
s
Organ specific symptoms
Signs
Organ specific signs
Macroglossia
Hypertension
Lymphadenopathy
Hepatomegaly
Splenomegaly
Purpura
Nephrotic Syndrome
Edema
Joint Pain
,
Muscle
pain
Serous cavity fluid
Labs
Biopsy under Congo red or thioflavine-T staining
Exam of
Gingiva
,
Rectum
, involved tissues
Green birefringence in polarized light
Serum
Immunoglobulin
s altered
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