Diffuse

Amyloidosis

search

Amyloidosis

  • Pathophysiology
  1. Disturbed endogenous protein metabolism
    1. Primary
    2. Secondary to chronic tissue breakdown
  2. Organ dysfunction arises from deposition
  • Symptoms
  1. Asthenia
  2. Weight loss
  3. Paresthesias
  4. Organ specific symptoms
  • Signs
  • Labs
  1. Biopsy under Congo red or thioflavine-T staining
    1. Exam of Gingiva, Rectum, involved tissues
    2. Green birefringence in polarized light
  2. Serum Immunoglobulins altered