CV
Polyarteritis Nodosa
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Polyarteritis Nodosa
See Also
Vasculitis
Epidemiology
Prevalence
: May approach 33 Million cases worldwide
Gender: Slight male predominance
Age: 30-40 years old
Classification
ANCA
negative
Vasculitis
Now differentiated from microscopic polyangitis
Pathophysiology
Medium vessel
Vasculitis
involving muscular arteries
Can affect any organ (esp.
Kidney
, skin, joint, muscle, nerve,
Intestine
), but typically does not involve the lung
Effects are related to vessel wall thickening, vessel narrowing and ultimately arterial
Occlusion
with secondary tissue infarction
Associated Conditions
Hepatitis B
Infection
Hepatitis C
Infection
Hairy Cell Leukemia
Symptoms
Fever
Weight loss
Hypertension
Abdominal Pain
Melena
Peripheral neuritis
Signs
Skin
Tender erythematous
Nodule
s similar to
Erythema Nodosum
Palpable
Purpura
Livedo reticularis
Skin Ulceration
Vesicobullous lesions
Signs
Systemic
Renal Insufficiency
Hypertension
Mononeuropathy Multiplex
Neuropathy
Myopathy
Mesenteric arteritis
Coronary ischemia
Labs
Vasculitis
labs (evaluate differential diagnosis)
ANCA
negative
Serum Creatinine
Creatinine
Phosphokinase (CPK)
Liver Function Test
s
Hepatitis B Surface Antigen
Anti-
Hepatitis C Antibody
Urinalysis
C-Reactive Protein
(negative result would suggest alternative diagnosis)
Imaging
Chest XRay
(evaluate differential diagnosis)
Diagnosis
Tissue Biopsy
Imaging (CT Angiogram, MR Angiogram)
Differential Diagnosis
See
Vasculitis
Infection
Endocarditis
Mycotic aneurysm
Hepatitis B
Infection
Hepatitis C
Infection
HIV Infection
Non-infectious causes
Atypical thromboembolic conditions (e.g. atrial myoma, antiphospholipid
Antibody
syndrome)
Fibromuscular dysplasia
Management
Corticosteroid
s
References
Merkel (2011) in UpToDate, Clinical features and diagnosis of
Takayasu Arteritis
, Accessed 11/30/11
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