Potassium

Familial Periodic Paralysis

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Familial Periodic Paralysis, Hypokalemic Periodic Paralysis

  • Epidemiology
  1. Onset of symptoms before age 20 years
  2. Males
  • Pathophysiology
  1. Autosomal Dominant disorder of Hypokalemia
  2. Potassium shifts into tissues
  • Risk Factors
  1. Alcohol Abuse
  2. Corticosteroid use
  3. Renal disease
  • Symptoms
  1. Headaches
  2. Thirst
  3. Lethargy
  4. No associated pain
  • Signs
  1. Slow progressive weakness
  2. Intermittent muscular paralysis
    1. Shoulder
    2. Pelvic girdle
    3. Other areas follow
  3. Muscle Strength normal between attacks
  4. Deep Tendon Reflexes
    1. Diminished or absent
  • Associated Conditions
  1. Thyrotoxicosis
    1. Especially in young asian males, with onset after Exercise
  • Management
  1. Replace Potassium
  2. Avoid high carbohydrate intake
  3. Avoid excessive salt intake