Pharm
Ziprasidone
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Ziprasidone
, Geodon
See Also
Antipsychotic Medication
Psychosis
Indications
Schizophrenia
(including acute episodic
Agitation
)
Mania
Bipolar Disorder
Tourette's Syndrome
(not FDA approved)
Mechanism
Primarily a
Serotonin
2A antagonist (
Dopamine
antagonist activity is much less)
Class
Atypical Antipsychotic
(Second
Gene
ration agent)
Dosing
Oral
Ziprasidone 20 to 80 mg orally twice daily
Parenteral
Ziprasidone 10 to 20 mg IM
Advantages
Minimal weight gain than with other
Atypical Antipsychotic
s
Lower risk of diabetes than with other
Atypical Antipsychotic
s
Drug Interactions
Increase
Antipsychotic
levels (toxicity risk): Monitor for toxicity
Clarithromycin
Erythromycin
Grapefruit
juice
Fluconazole
Itraconazole
Ketoconazole
Decrease
Antipsychotic
levels (lower efficacy)
Carbamazepine
Phenytoin
Adverse Effects
Lower
Extrapyramidal Side Effect
s compared with other
Antipsychotic
s
Somnolence
(esp.
Overdose
)
Nausea
Weakness
QTc Prolongation
(more than with other
Atypical Antipsychotic
s)
Monitoring
See
Antipsychotic
s
References
Glauser and Peters (2016) Crit Dec Emerg Med 30(4): 17-27
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