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Serotonin Antagonist and Reuptake Inhibitor

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Serotonin Antagonist and Reuptake Inhibitor, SARI

  • Mechanism
  1. Phenylpiperazine Antidepressant (Serzone prototype)
  2. Unrelated to Tricyclic Antidepressants
  3. Serotonin Antagonist and Reuptake Inhibitor (SARI)
    1. Blocks 5-HT-2 postsynaptic receptor
  • Medications
  1. Desyrel (Trazodone)
  2. Nefazodone (Serzone)