Pharm

Norpramin

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Norpramin, Desipramine, Pertofrane

  • Dosing
  1. Start: 50 mg PO qd for 3 days
  2. Next: 50 mg PO bid for 3 days
  3. Next: 100 PO qhs for 3 days
  4. Therapeutic dose: 150 PO qhs
  5. Maximum: 250 mg PO qhs
  • Pharmacokinetics
  1. Serum Half Life: 21 hours
  2. Therapeutic plasma level: 125 to 300
  • Adverse effects
  1. See Tricyclic Antidepressants
  2. Much less adverse effects than tertiary amines
  3. Moderate adverse effects
    1. Orthostatic Hypotension
    2. Cardiac Arrhythmia
  • Precautions
  1. See Tricyclic Antidepressants
  2. Serious cardiotoxicity in overdosage
  • Advantages
  1. Activating
  2. Inexpensive
  3. Attention Deficit Hyperactivity Disorder effect