Pharm
Haloperidol
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Haloperidol
, Haldol, Haloperidol Lactate, Haloperidol decanoate
See Also
Antipsychotic Medication
Psychosis
Indications
Psychosis
Delirium
Schizophrenia
Tic Disorder
s (including
Tourette's Syndrome
)
Acute
Mania
Contraindications
Pregnancy and
Lactation
Phencyclidine
(PCP)
Overdose
Anticholinergic Syndrome
s
Alcohol
or
Benzodiazepine Withdrawal
Hepatic Insufficiency
Neuroleptic Malignant Syndrome
Class
First
Gene
ration
Antipsychotic
Dosing
Haloperidol
Dose
Adult: 5-10 mg PO, IM, or IV
Peds: 0.5-1 mg PO, IM or IV
Adolescent: 1-5 mg PO, IM or IV
Elderly: 0.5-2 mg PO, IM or IV
Intervals: Scheduled and repeated dosing intervals
May repeat every 30-60 minutes
Maximum: 300 mg/24 hours (avoid cummulative dose over 100 mg in 24 hours)
May dose regularly every 6-8 hours
Typical effective dose: 5 mg PO, IV, or IM tid (lower doses in the elderly)
Total dose >3 mg/day is associated with
Extrapyramidal Side Effect
s
Dosing
Haloperidol decanoate (depot form)
Haloperidol decanoate 100 mg IM every 4 weeks
Cost effective (may be as low as $19 generic)
Precautions
Intravenous doses have a much shorter duration of action than other routes
Antipsychotic
s are associated with increased mortality in the elderly
Adverse effects
Serious
See
Extrapyramidal Side Effect
s (EPSE)
Neuroleptic Malignant Syndrome
Hypotension
Dystonia
Seizure
s
Prolonged QT
interval
Risk of
Torsades de Pointes
Dose related effect with higher risk at higher doses
Common
Insomnia
Restlessness
Anxiety
Sedation
Headache
Weight gain
Hyperprolactinemia
Blood dyscrasia
Monitoring
Serum Prolactin
Obtain if indicated
Complete Blood Count
(indicated if history of
Leukopenia
)
Baseline
Monthly in first 3 months of therapy
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