Pharm
Duloxetine
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Duloxetine
, Cymbalta
See Also
Serotonin
-
Norepinephrine
Reuptake Inibitors (
SNRI
)
Desvenlafaxine
Venlafaxine
Indications
Major Depression
Generalized Anxiety Disorder
Diabetic Neuropathy
Fibromyalgia
Contraindications
Chronic Liver Disease
Serotonin Syndrome
Glomerular Filtration Rate
<30 ml/min
Mechanism
Strong
Serotonin
and
Norepinephrine
reuptake inhibitor
Also with minor
Dopamine
reuptake inhibitor properties
Preparations
Duloxetine Hydrochloride delayed release tablets (20g, 30 mg, 60 mg)
Dosing
Start: 20 mg twice daily or 30 mg daily
Advance to 60 mg daily (or divided twice daily)
Drug Interactions
Monoamine Oxidase Inhibitor
s (
MAO inhibitor
)
Do not use Duloxetine concurrently or within 14 days of last dose of
MAO inhibitor
s
Linezolid
Methylene Blue
Safety
Pregnancy Category: C
Black box warning as for all
Antidepressant
s for
Suicidality
in teens
Adverse Effects
Nausea
Xerostomia
(
Dry Mouth
)
Somnolence
Constipation
Decreased Appetite
Hyperhidrosis
Urinary Retention
References
Jaouen and Lovecchio (2021) Crit Dec Emerg Med 31(12): 24
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