Pharm

Duloxetine

search

Duloxetine, Cymbalta

  • See Also
  • Mechanism
  1. Strong Serotonin and Norepinephrine reuptake inhibitor
  2. Also with minor Dopamine reuptake inhibitor properties
  • Preparations
  1. Duloxetine Hydrochloride delayed release tablets (20g, 30 mg, 60 mg)
  • Dosing
  1. Start: 20 mg twice daily or 30 mg daily
  2. Advance to 60 mg daily (or divided twice daily)
  • Drug Interactions
  1. Monoamine Oxidase Inhibitors (MAO inhibitor)
    1. Do not use Duloxetine concurrently or within 14 days of last dose of MAO inhibitors
  2. Linezolid
  3. Methylene Blue
  • Safety
  1. Pregnancy Category: C
  2. Black box warning as for all Antidepressants for Suicidality in teens
  • References
  1. Jaouen and Lovecchio (2021) Crit Dec Emerg Med 31(12): 24