Pharm

Duloxetine

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Duloxetine, Cymbalta

  • See Also
  1. Serotonin-Norepinephrine Reuptake Inibitors (SNRI)
  2. Desvenlafaxine
  3. Venlafaxine
  • Indications
  1. Major Depression
  2. Generalized Anxiety Disorder
  3. Diabetic Neuropathy
  4. Fibromyalgia
  • Contraindications
  1. Chronic Liver Disease
  2. Serotonin Syndrome
  3. Glomerular Filtration Rate <30 ml/min
  • Mechanism
  1. Strong Serotonin and Norepinephrine reuptake inhibitor
  2. Also with minor Dopamine reuptake inhibitor properties
  • Preparations
  1. Duloxetine Hydrochloride delayed release tablets (20g, 30 mg, 60 mg)
  • Dosing
  1. Start: 20 mg twice daily or 30 mg daily
  2. Advance to 60 mg daily (or divided twice daily)
  • Drug Interactions
  1. Monoamine Oxidase Inhibitors (MAO inhibitor)
    1. Do not use Duloxetine concurrently or within 14 days of last dose of MAO inhibitors
  2. Linezolid
  3. Methylene Blue
  • Safety
  1. Pregnancy Category: C
  2. Black box warning as for all Antidepressants for Suicidality in teens
  • Adverse Effects
  1. Nausea
  2. Xerostomia (Dry Mouth)
  3. Somnolence
  4. Constipation
  5. Decreased Appetite
  6. Hyperhidrosis
  7. Urinary Retention
  • References
  1. Jaouen and Lovecchio (2021) Crit Dec Emerg Med 31(12): 24