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Antidepressant Adverse Effects

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Antidepressant Adverse Effects

  • Adverse Effects
  • Least Tolerated Agents (early discontinuation)
  1. Most: Tricyclic Antidepressants (Tertiary amines)
  2. Least: SSRI, Bupropion, SARI, MAO inhibitors
  • Adverse Effects
  • Weight gain (Histamine H1 receptor blockade)
  1. Most: Tricyclic Antidepressants (Tertiary amines)
  2. Least: Bupropion, SSRI
  1. SSRI and SNRI agents increase risk of bleeding events when combined with Anticoagulants and antiplatelet agents
    1. Drug Interactions occur primarily with Warfarin
    2. One additional patient on Warfarin for Atrial Fibrillation with SNRI or SSRI will have have a major bleeding event
      1. However, also affect other Anticoagulants such as Pradaxa and antiplatelet agents
  2. Most: Fluoxetine, Flovoxamine (especially with Warfarin)
  3. Least: Mirtazapine, Bupropion
  4. References
    1. (2014) Presc Lett 21(11): 65
    2. Sansone (2009) Psychiatry 6(7): 24–29 [PubMed]
  1. Most: Tricyclic Antidepressants (Tertiary amines)
  2. Least: Bupropion, SSRI
    1. Although QT Prolongation has been seen with Citalopram and Escitalopram
  • Adverse Effects
  • Gastrointestinal effects (Serotonin reuptake blockade)
  • Adverse Effects
  • Sedation (Histamine H1 receptor blockade)
  • Adverse Effects
  • Miscellaneous