Pharm

Amitriptyline

search

Amitriptyline, Elavil

  • Background
  1. Cost: $5.30 per month
  • Pharmacokinetics
  1. Serum Half Life: 21 hours
  2. Therapeutic plasma level: 110 to 250
  1. Initial: 25 mg PO qhs
  2. Morning Hangover Effect: Taper to 10 mg PO qhs
  • Dosing
  • Depression (listed for historical purposes only)
  1. Avoid for Depression given adverse effects
  2. SSRIs and other new Antidepressants are preferred
  3. Dose: 150-300 mg qhs
  • Adverse effects
  1. See Tricyclic Antidepressants
  2. Significant adverse effects
    1. Sedation and morning grogginess
    2. Anticholinergic Symptoms
    3. Orthostatic Hypotension
    4. Cardiac arrhythmia
    5. Weight gain
  • Precautions