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Barbiturate Abuse

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Barbiturate Abuse, Barbiturate withdrawal

  • Preparations
  • Forms
  1. Phenobarbital
  2. Nembutal
  3. Seconal
  4. Amytal
  • Preparations
  • Street Names
  1. Blue Devils
  2. Yellow Jackets
  3. Blue Heavens
  4. Downers
  5. Barbs
  • Pharmacokinetics
  1. Seconal (30-500 mg): 6-8 hours duration
  • Signs
  • Withdrawal
  1. Supportive care with airway management for CNS Depression (similar to Benzodiazepines)
  2. Urine Alkalinization with Sodium Bicarbonate
  • Management
  • Withdrawal Protocol (Barbiturate Taper)
  1. See also Barbiturate Equivalents
  2. Pentobarbital challenge (shorter half life)
    1. Start: 200 mg Pentobarbital
    2. Then: 100 q2 hours until mildly intoxicated
  3. Switch to Phenobarbital
    1. Convert: 30 mg Phenobarbital = 100 mg Pentobarbital
    2. Decrease Phenobarbital by 10% per day