Drug Metabolism


Drug Metabolism, Medication Kinetics, Drug Pharmacokinetics, Absorption Distribution Metabolism Excretion, ADME

  • See Also
  • Definitions
  1. Pharmacokinetics (or kinetics)
    1. Absorption, Distribution, Metabolism and Excretion (ADME)
  • Types
  • Proteins that increase drug water solubility and in turn aid elimination
  1. Cytochrome P450
    1. Enzymes: CYP1A2, CYP2C9, CYPC19, CYP2D6, CYP2E1, CYP3A4
  2. Uridine Diphosphate-glucuronosyltransferase (UGT) Conjugating Enzyme
    1. Glucuronosyltransferases perform glucuronidation primarily in the liver and aid drug excretion
  • Types
  • Transport proteins move drugs and metabolites from one body compartment to another
  1. Adenosine Triphosphate binding casette (ABC) drug uptake/efflux transporters
    1. Enzymes: Efflux pump P-Glycoprotein (P-gp)
  2. Organic anion-transporting polypeptide (OATP) drug transporters
    1. Enzymes: OATP1A1, OATP1A2, OATP2B1