Metabolism
Cytochrome P-450
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Cytochrome P-450
, Cytochrome P450, CYP450
Background
Central to hepatic metabolism of medications
Cytochrome P450 enzymes are responsible for 80% of drug-
Drug Interaction
s
Primary role of CYP enzymes is to facilitate drug excretion by increasing water solubility
Types
Cytochrome P-450 Isoenzymes
Hepatic Isoenzymes
CYP3As
(40-60% hepatic P-450 isoenzymes)
CYP2D6
(2-5% hepatic P-450 isoenzymes)
CYP2As (<1% hepatic P-450 isoenzymes)
CYP1A2
CYP2Cs
Other Isoenzymes
CYP1A1
CYP2Bs
CYP2E1
CYP4As
References
(1999) Med Lett Drugs Ther 41(1056): 61-2 [PubMed]
Ament (2000) Am Fam Physician 61(6): 1745-54 [PubMed]
Bhatia (1997) Am Fam Physician 55(5):1683-94 [PubMed]
Flockhart (2002) Arch Intern Med 162:405-12 [PubMed]
Johnson (1999) Postgrad Med 105(2):193-222 [PubMed]
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