Metabolism

Cytochrome P-450

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Cytochrome P-450, Cytochrome P450, CYP450

  • Background
  1. Central to hepatic metabolism of medications
  2. Cytochrome P450 enzymes are responsible for 80% of drug-Drug Interactions
  3. Primary role of CYP enzymes is to facilitate drug excretion by increasing water solubility
  • Types
  • Cytochrome P-450 Isoenzymes
  1. Hepatic Isoenzymes
    1. CYP3As (40-60% hepatic P-450 isoenzymes)
    2. CYP2D6 (2-5% hepatic P-450 isoenzymes)
    3. CYP2As (<1% hepatic P-450 isoenzymes)
    4. CYP1A2
    5. CYP2Cs
  2. Other Isoenzymes
    1. CYP1A1
    2. CYP2Bs
    3. CYP2E1
    4. CYP4As
  • References
  1. (1999) Med Lett Drugs Ther 41(1056): 61-2 [PubMed]
  2. Ament (2000) Am Fam Physician 61(6): 1745-54 [PubMed]
  3. Bhatia (1997) Am Fam Physician 55(5):1683-94 [PubMed]
  4. Flockhart (2002) Arch Intern Med 162:405-12 [PubMed]
  5. Johnson (1999) Postgrad Med 105(2):193-222 [PubMed]