Analgesic

Nalmefene

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Nalmefene, Revex

  • Indications
  1. Narcotic Toxicity requiring frequent Naloxone dosing
  • Precautions
  1. Do not use as first line agent for Narcotic Toxicity
  2. Risk of severe Narcotic Withdrawal
  • Pharmacokinetics
  1. Long acting Opioid antagonist
  2. Duration: 4-8 hours
  • Dosing
  1. Opioid Overdose
    1. Initial: 0.5 mg per 70 kg person IV
    2. Later: 1 mg per 70 kg IV prn 5 min after initial dose
    3. Narcotic dependent: 0.1 mg per 70 kg test dose
  2. Post-operative Narcotic reversal
    1. Dose: 0.25 ug/kg IV q2-5 minutes
    2. Maximum: 1 ug/kg total dose