Analgesic

Hydromorphone

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Hydromorphone, Dilaudid

  • See Also
  • Dosing
  • Adults (or children over age 12 years)
  1. Oral
    1. Hydromorphone 2-4 mg orally as needed every 4-6 hours
  2. Parenteral: SC or IM
    1. Hydromorphone 0.5 to 2 mg SC or IM as needed every 4-6 hours
  3. Parenteral: IV
    1. Hydromorphone 0.5 mg slow IV over 2-5 min every 15 min as needed for 3 doses or
    2. Hydromorphone 1 mg slow IV over 2-5 min every 2 hours as needed
  • Dosing
  • Children (under age 12 years)
  1. Oral
    1. Hydromorphone 0.03 to 0.08 mg/kg up to 2-4 mg orally as needed every 4-6 hours
  2. Parenteral: IV
    1. Hydromorphone 0.015 mg/kg/dose up to 0.5 to 2 mg slow IV over 2-5 min as needed every 4-6 hours
  • Adverse Effects
  • Precautions
  1. Hydromorphone 1 mg IV is equivalent to 7 mg Morphine Sulfate IV
  2. Hydromorphone more easily crosses blood-brain barrier than other Opioids
    1. Risk of excessive sedation and respiratory depression
  3. Hydromorphone is renally excreted (clearance may be delayed 40 hours in Renal Failure)