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Herbal Remedy

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Herbal Remedy, Alternative Medicine, Natural Product, Chinese Herbal Medicine, Herbal Toxicity, Herbal Interaction, Herbal Medicine, Herbals

  • Epidemiology
  • United States
  1. Adults on Herbals and prescribed medication: 15 Million
    1. Adults alerting doctor of concurrent herbal use: 50%
  2. Americans spent $4 billion on Herbals in 1998
  3. Worldwide use: 4 billion people
  4. Most commonly used herbal products in the United States
    1. Echinacea
    2. St. John's Wort
    3. Ginkgo Biloba
    4. Garlic
    5. Saw Palmetto
    6. Ginseng
    7. Goldenseal
    8. Aloe
    9. Siberian Ginseng
    10. Valerian
  • Background
  1. Traditional medicine is basis for 80% world healthcare
  2. Most medications are synthesized from plant sources
    1. Plant Derivatives: 75% of modern medications
    2. Direct Extracts: 25% of modern medications
  3. Little efficacy data exists for Herbals
    1. Only 30-40 of 1200 herbs have evidence of benefit
    2. Prescribed medications by contrast must show benefit
  4. Modern drugs directly derived from plant sources
    1. Acetylsalicylic acid (Aspirin) from willow bark
    2. Atropine from deadly nightshade plant
    3. Cantharidin from Blister beetle (for Wart Treatment)
    4. Colchicine from meadow saffron plant
    5. Cortisone from Mexican Discorea species
    6. Digitalis (Digoxin) from the foxglove plant
    7. Morphine and other Narcotics from the opium poppy
    8. Pilocarpine from the South American Jaborandi Tree
    9. Podophyllin or Podophyllum from mayapple plant
    10. Pyrethrins from chrysanthemums (for lice treatment)
    11. Quinine from yellow cinchona
    12. Reserpine from the snakeroot plant
    13. Scopolamine from Colombian Datura arborea tree
    14. Senna Laxatives from the senna plant
    15. Taxol from the yew tree
    16. Vincristine, Vinblastine from rosy periwinkle plant
    17. Yohimbine from black currant trees (Rubiaceae)
  • Disadvantages
  • Related to herbal medication use
  1. No enforced labeling of efficacy
  2. No quality control regulation
    1. USP Verified Mark may be found on some products
  3. Adverse effects are not routinely labeled
    1. See below as well as specific herbal medications
    2. Serious Drug Interactions may exist
      1. St. John's Wort reduces Oral Contraceptive effectiveness
      2. American Ginseng decreases INR for patients on Warfarin
  4. No standardization of concentration and potency
    1. Many herbal preparations are mislabeled
    2. Some contain little if any active ingredient
  5. Preparations may contain contaminants
    1. Pesticides
    2. Heavy metals (often found in folk remedies)
      1. Arsenic
      2. Mercury
      3. Lead (see Lead-Containing Herbal Remedies)
      4. Cadmium
    3. Prescription drugs illicitly placed in product
      1. Phenylbutazone
      2. Aminopyrine
      3. Prednisone
      4. Testosterone
      5. Diazepam
      6. Indomethacin
  6. Serious Drug Interactions may occur
    1. Goldenseal (high risk of interactions with multiple agents)
    2. St John's Wort (high risk of interactions with multiple agents)
    3. Ginkgo Biloba (increased bleeding risk with Warfarin)
    4. Milk Thistle (multiple interactions)
    5. Asian Ginseng (multiple interactions)
    6. Curcumin (decreases levels of many psychiatric medications)
  7. Many plants are highly poisonous (fatal at low dose)
    1. Deadly nightshade
    2. Hemlock
    3. Mistletoe
    4. Oleander
    5. Daphne Berry
    6. Rosary Pea
    7. Jasmine
    8. Red sage
    9. Yew
    10. http://aggie-horticulture.tamu.edu/earthkind/landscape/poisonous-plants-resources/common-poisonous-plants-and-plant-parts/
  • Adverse Effects
  1. General
    1. Patient should report adverse effects to physician
    2. Notify FDA of adverse effects
      1. FDA MedWatch
        1. http://www.fda.gov/medwatch/
        2. Phone: 1-800-332-1088
  2. Cyanide Poisoning risk with seeds, bark, or leaves
    1. Apricot
    2. Cassava beans
    3. Cherries
    4. Choke cherries
    5. Peaches
    6. Plums
  3. Hepatotoxicity
    1. See Hepatotoxin
  4. Allergic Reaction Risk for those with ragweed allergy
    1. Goldenrod
    2. Marigold
    3. Yarrow
    4. St. John's Wort
    5. Chamomile (or Mayweed or dog fennel)
  5. Anticholinergic and Hallucinogenic Risks
    1. Catnip
    2. Juniper
    3. Lobelia
    4. Jimsonweed
    5. Wormwood
    6. Nutmeg
  6. Laxative abuse risk
    1. Buckthorn bark
    2. Senna
    3. Dock roots
    4. Aloe vera
  7. Abortion risk in pregnancy
    1. Devil's claw root
    2. Barberry
    3. Dong Quai
    4. High concentrations of Ruta, Hydrastis or Oregano
  8. Bleeding risk (Anticoagulant activity)
    1. Ginkgo Biloba
    2. Feverfew
    3. Garlic
    4. Ginseng
    5. Dong Quai
    6. Red Clover
  9. Cardiovascular effects
    1. See Herbals Affecting Blood Pressure
    2. Arrhythmias
      1. Yohimbine
    3. Strong Stimulants (result in ED visits for Palpitations, Chest Pain)
      1. See Ephedra and Caffeine
      2. Guarana
      3. Yerba mate
      4. Kola nut
      5. Bitter Orange
  • History
  1. Do you use Alternative Medicines?
    1. Herbal Product?
    2. Herbal Supplement?
    3. Natural Remedy?
  2. What other prescribed or OTC medications do you use?
  3. For how long have you used this herbal product?
  4. Do you have any allergies to plant products?
  5. Are you currently pregnant or Breast Feeding?
  • Precautions
  • Pointers for patients purchasing herbal products
  1. Purchased products should be labeled appropriately
    1. Botanical name of herb
    2. Strength or concentration of active ingredient
    3. Batch or lot number
    4. Expiration date
    5. Name of manufacturer and contact information
  2. Avoid herbal products in pregnancy and Lactation
    1. Be particularly cautious in first trimester
    2. See adverse effects above or see specific herb
  3. Use herbal therapies with caution if immunocompromised
    1. Herbal therapies may be contaminated with microbes
  4. Use the lowest effective dose of a product
  5. Avoid prolonged use of any product
  6. Stop herbal therapies 2 weeks before elective surgery
  7. Avoid mixing herbal products
  8. Discuss herbal use with your physician
    1. Discuss potential Drug Interactions with physician
    2. Discuss adverse effects (see above)
    3. Reevaluate efficacy and safety on regular basis
  9. Avoid potentially sedating agents prior to driving or other activity requiring full concentration
    1. Relaxation drinks (e.g. Neuro Bliss, Just Chill, Marley's Mellow Mood)
      1. Contain Valerian Root, Kava xtract, GABA and Melatonin
      2. (2014) Presc Lett 21(1): 5
  10. Check manufacturer quality
    1. ConsumerLab.com
      1. http://www.consumerlab.com