Alternative
Glucosamine
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Glucosamine
, Glucosamine Sulfate
See Also
Osteoarthritis
Chondroitin
Pathophysiology
Glucosamine is endogenous amino sugar, a precursor of glycosaminoglycans
Glycosaminoglycans are present in joint structures such as
Synovial Fluid
Effects
Stimulates chondrocyte metabolism
May have anti-inflammatory effects at higher dose
Source
Marine exoskeleton or
Synthetically derived
Efficacy
Appears more effective than
Placebo
at relieving pain
Effect requires at least one month of therapy
Less
Knee Joint
space narrowing with Glucosamine over
Placebo
in 3 years
Reginster (2001) Lancet 357:251-6 [PubMed]
Dosing
Glucosamine 500 mg orally three times daily
Adverse Effects
Gastrointestinal upset
Hemoglobin A1C
and
Serum Glucose
are NOT impacted (contrary to initial reports)
Scroggie (2003) Arch Intern Med 163:1587-90
Glucosamine is safe in shellfish allergy (despite marine exoskeleton source)
Gray (2004) J Allergy Clin Immunol 114:459-60 [PubMed]
Drug Interactions
Warfarin
(
Coumadin
)
Warfarin
's
Anticoagulation
effect is increased
References
Delafuente (2000) Rheum Dis Clin North Am 26:1-11 [PubMed]
McAlindon (2000) JAMA 283:1469-75 [PubMed]
Richy (2003) Arch Intern Med 163:1514-22 [PubMed]
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