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Feverfew

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Feverfew, Tanacetum parthenium

  • Indications (Purported uses)
  1. Migraine Headache prevention
  • Efficacy
  1. Some studies support benefit for Migraine prevention
  2. No benefit in Rheumatoid Arthritis
  • Mechanism
  1. Inhibits prostaglandin synthesis
  2. Serotonin antagonist
  3. Inhibits platelet aggregation
  • Dosing
  1. Standard extract 125 mg (at least 0.2% parthenolide)
  • Adverse Effects
  • Contraindications
  1. Pregnancy
    1. Feverfew may induce menstruation
  2. Concurrent Anticoagulant use or peri-operative
    1. Feverfew increases bleeding risk
  • References
  1. Shaughnessy (1997) Fam Practice Recert 19(10):53-6
  2. Zink (1998) Am Fam Physician 58(5): 1133-40 [PubMed]