Pharm

Pemoline

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Pemoline, Cylert

  • Indications
  1. Attention Deficit Hyperactivity Disorder (ADHD)
    1. No longer available in United States
    2. Not recommended for use due to hepatotoxicty
  • Pharmacokinetics
  1. Onset: 2 hours
  2. Duration: 6 to 10 hours
  3. Steady state reached in 2 to 3 days
  4. Titrate dose every 3 to 4 weeks
  • Dosing
  1. Range: 0.5 - 2.5 mg/kg/dose (Up to 112.5 mg/day)
  2. Start: 18.75 mg PO qAM
  3. Frequency: Once to twice daily
  • Monitoring
  1. Alanine Aminotransferase (ALT)
    1. Obtain baseline
    2. Repeat testing every 2 weeks
  2. Symptom inquiry at every visit
    1. Anorexia
    2. Malaise
    3. Gastrointestinal symptoms
    4. Dark Urine
  • Precautions
  1. Informed Consent from parents required prior to use
  • Adverse Effects
  1. Hepatic failure of dysfunction
  2. Choreoathetoid movements
  3. Other adverse effects similar to Methylphenidate