Pharm

Oxytocin

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Oxytocin, Pitocin

  • Adverse effects
  1. Uterine hypertonicity
    1. Uterine tetanic contractions and Fetal Distress
    2. Uterine Rupture
  2. Water Intoxication (SIADH)
    1. Associated with slow infusion >24 hours
  • Pharmacokinetics of intravenous Oxytocin
  1. Onset: 1 minute
  2. Duration: 30 minutes
  3. Half-life: <5 minutes
  • Dosing
  1. See Labor Induction
  2. Postpartum Hemorrhage prevention after Vaginal Delivery
    1. Oxytocin 10 units IM after delivery
    2. Oxytocin 10-40 units in 1 L IV fluid (NS, LR, D5W)
  3. Postpartum Hemorrhage prevention after cesarean
    1. High dose Oxytocin prevents atony
    2. Dose: Oxytocin 2667 mU/min for 30 minutes
    3. Munn (2001) Obstet Gynecol 98:386-90 [PubMed]