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Symmetric Peripheral Neuropathy

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Symmetric Peripheral Neuropathy, Polyneuropathy

  • Causes
  • Proximal or distal sensorimotor Neuropathy (Type 1)
  1. Acute Inflammatory Demyelinating Polyneuropathy
    1. Guillain-Barre Syndrome
  2. Chronic Inflammatory Demyelinating Polyneuropathy
  3. Primary Myelinopathy
  4. Malignancy
  5. HIV or AIDS
  6. Hepatitis B
  7. Buckthorn
  8. Diphtheria
  • Causes
  • Distal sensorimotor Polyneuropathy or DSPN (Type 2)
  1. Diabetic Neuropathy (Diabetic DSPN)
  2. Alcoholism induced Neuropathy (Alcoholic DSPN)
  3. HIV or AIDS
  4. Malignancy (paraneoplastic syndrome)
  5. Charcot-Marie-Tooth
  6. Toxins
    1. Acrylamide
    2. Allyl chloride
    3. Carbon disulfide
    4. Ethylene oxide
    5. Hexacarbons
    6. Trichloroethylene
    7. OPIDP, PCBs, PNU
    8. Organophosphates
    9. Nitrous Oxide Abuse (due to secondary Vitamin B12 Deficiency)
  7. Metals
    1. Arsenic
    2. Lead Poisoning
    3. Gold
    4. Mercury
    5. Thallium
  8. Medications
    1. See Drug-Induced Polyneuropathy
  9. Vitamin Deficiency
    1. Thiamine deficiency (Beriberi)
    2. Niacin Deficiency (Pellagra)
    3. Vitamin B12 Deficiency (Pernicious Anemia)
    4. Nitrous Induced Subacute Combined Degeneration of the Spinal Cord
    5. Vitamin B6 deficiency
  10. Paraproteinemia
    1. Amyloidosis
    2. Multiple Myeloma
    3. Waldenstrom's Macroglobulinemia
  11. Miscellaneous causes
    1. Acromegaly
    2. Chronic lung disease
    3. Hypothyroidism
    4. Renal Failure
    5. Porphyria
    6. Chronic Liver Disease
    7. Tic Paralysis
  • References
  1. Gallagher in Marx (2002) Rosen's Emergency Med, p. 1506
  2. Pryse-Phillips in Noble (2001) Primary Care, p. 1579