Pharm
Topiramate
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Topiramate
, Topamax
Indications
Simple Partial Seizure
s
Complex Partial Seizure
s
Generalized Tonic Clonic Seizure
s
Adverse Effects
Dose related
Interferes with concentration and memory
Refered to pejoratively by some as "Dopamax"
Confusion
Sedation
Lethargy
Dizziness
Ataxia
Diplopia
Tremor
Nervousness
Fatigue
Depression
Anorexia
Dyspepsia
Adverse Effects
Other
Nephrolithiasis
Narrow Angle Glaucoma
Drug Interactions
Other
Seizure
medications
Dose
Adult
Initial: 25-50 mg/day (consider start just qhs)
Increase by 25-50 mg/day increments per week
Target
Adults: 400 mg/day divided bid
Elderly: 200 mg/day divided bid
Maximum dose: 1600 mg/day divided bid
Dose
Child
Initial: 1-3 mg/kg up to 25 mg PO qhs for 1 week
Increase by 1-3 mg/kg/day to 25 mg increments per week
Target range: 5-9 mg/kg/day divided bid
Precautions
Adjust dose if
Creatinine Clearance
<60 ml/min/sec
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