Pharm
Ropinirole
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Ropinirole
, Requip
See Also
Dopamine Agonist
Mirapex
(
Pramipexole
)
Indications
Parkinson's Disease
Restless Leg Syndrome
Pharmacokinetics
Half life: 6 hours
Hepatic metabolism
Dosing
Parkinsonism
Immediate Release start 0.25 mg three times daily (may increase by 0.25 mg/week up to 24 mg/day)
Extended Release start 2 mg daily (may increase by 2 mg/week up to 24 mg/day)
Dosing
Restless Leg Syndrome
Start: Requip 0.25 mg orally taken 2-3 hours before bedtime
Interval for increasing dose: 3-7 days
Titrating dose: Increase at set interval as above by one tablet if ineffective at current dose
Start at 0.25 mg one tablet nightly for set interval in days
Increase to two tablets (0.50 mg) nightly for set interval if ineffective at 0.25 mg
Increase to three tablets (0.75 mg) nightly for set interval if ineffective at 0.50 mg
Maximum dose: 6 tablets (1.5 mg) taken at bedtime
Stopping: No titration needed
Adverse Effects (similar to Mirapex)
Nausea
(common)
Drowsiness (Limited to higher dosages)
May be sudden, severe without warning
May occur up to one year after starting
Mirapex
Has resulted in falling asleep while driving
Augmentation of Restless Leg Symptoms
Occurs in 25% of RLS patients on longterm therapy
May progress in severity, and involve arms, trunk
Often better if dose timing changed to earlier in day
May be worse if dose increased
Other uncommon adverse effects (rare at low dose)
Hallucination
s
Pathologic Gambling
(related to
Dopamine
receptor agonist activity, D3)
Orthostatic Hypotension
Hypersexuality
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