Pharm

Perampanel

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Perampanel, Fycompa

  • Indications
  1. Refractory partial-onset Seizures
  • Mechanism
  1. Antiepileptic
  2. Glutamate receptor antagonist (first in the class)
    1. Selective for AMPA receptors
  • Precautions
  1. FDA Schedule III
    1. Abuse potential due to associated euphoria
  • Adverse Effects
  1. Mood changes
    1. Euphoria
    2. Anger
    3. Hostility
  2. Dizziness
  3. Sedation
  • Dosing
  1. FDA approved for age over 12 years
  2. Initial: 2 mg orally at bedtime
  3. Titrate To: 4-8 mg orally at bedtime (increase by 2 mg/day on a weekly basis)
  4. Maximum: 12 mg/day
  • Drug Interactions
  1. Levonorgestrel containing contraceptives
    1. Perampanel decreases the contraceptive efficacy
    2. Use alternative agents
  • References
  1. (2014) Presc Lett 21(11): 65
  2. French (2012) Neurology 79(6):589-96 [PubMed]