Pharm

Oxcarbazepine

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Oxcarbazepine, Trileptal

  • Indications
  1. Simple Partial Seizures
  2. Complex Partial Seizures
  3. Generalized Tonic Clonic Seizures
  4. Trigeminal Neuralgia
  5. Mania
  • Adverse Effects
  • Dose related
  1. Nausea or Vomiting
  2. Dizziness or Vertigo
  3. Headache
  4. Ataxia
  5. Diplopia
  6. Sedation
  7. Lethargy
  8. Tremor
  9. Rash
  • Adverse Effects
  • Other
  1. Hyponatremia
  2. Cardiac arrhythmia
  • Dosing
  1. Child (age 4 to 16 years old)
    1. Initial: 8-10 mg/kg/day divided twice daily
    2. May be increased by 5 mg/kg/day up to every 3 days, up to maximum dose
  2. Adult (includes elderly)
    1. Initial: 300 mg (max 600 mg) orally twice daily
    2. Increase by 300 mg/day each week
  • References
  1. Liu (2017) Am Fam Physician 96(2): 87-96 [PubMed]