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Midodrine

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Midodrine

  • Indications
  • Mechanism
  1. Alpha agonist: constricts arterioles and veins
  2. Increases peripheral resistance
  • Efficacy
  1. Study: n=162, PCT
    1. Significantly improved standing BP and symptoms
  2. Reference
    1. Low (1997) JAMA 277:1046-51 [PubMed]
  • Adverse Effects
  1. Pilomotor reactions
  2. Urinary urgency and retention
  3. Supine Hypertension
  • Dosing
  1. Dose: 10 mg PO tid