Pharm
Alpha Adrenergic Receptor
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Alpha Adrenergic Receptor
, Alpha 1 Adrenergic Receptor, Alpha 2 Adrenergic Receptor
See Also
Adrenergic Receptor
Beta Adrenergic Receptor
Sympathetic Nervous System
Sympathomimetic Toxicity
Sympathomimetic
Effects
Alpha Receptor
Gene
ral
Vascular smooth muscle
Skin and skeletal muscle vessel constriction
Splanchnic vessel constriction
Gastrointestinal
Myenteric Plexus Inhibition
Genitourinary
Pregnant
Uterus
contraction
Penis
and seminal
Vesicle
ejaculation
Skin
Pilomotor smooth muscle contraction
Apocrine gland contraction
Metabolic
Gluconeogenesis
Glycogenolysis
Effects
Alpha 1 Receptors
Vascular smooth muscle postsynaptic
Neuron
s
Vasocon
striction
Myocardium
Positive Inotrope
Negative Chronotrope
Eye
Radial muscle contraction
Gastrointestinal and Genitourinary
Sphincter (e.g. anus) contraction
Effects
Alpha 2 Receptors
Peripheral Alpha 2 Receptors
Vascular Smooth Muscle (mixed effect)
Modulates large vessel tone
Arteriolar and venous
Vasocon
striction
Opposes alpha 1 receptor
Vasocon
striction
Inhibits
Norepinephrine
release
Decreases adrenergic activity
Gastrointestinal
Smooth muscle wall relaxation
Metabolic
Fat Cell Lipolysis
Central Alpha 2 Receptors (CNS)
Inhibits Locus Ceruleus reflex arc
Peripheral vasodilatation
Medications
Alpha Adrenergics
Alpha Adrenergic Agonist (Alpha Adrenergic Receptor)
Alpha Non-Specific
Epinephrine
Norepinephrine
Alpha 1 Selective
Phenylephrine
Methoxamine
Alpha 2 Selective
Clonidine
(See
Central Adrenergic Agonist
)
Alpha-methylnorepinephrine
Alpha Receptor Antagonist
Alpha Non-Specific
Phentolamine
Alpha 1 Selective
Prazosin
(See
Alpha Adrenergic Antagonist
)
Phenoxybenzamine
Alpha 2 Selective
Yohimbine
Tolazoline
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