Critical Illness Myopathy


Critical Illness Myopathy, Myopathy Following ICU Admission

  • Risk Factors
  • Impacts mobility and stair climbing after ICU admit
  1. Prolonged ICU Stay
  2. Poor baseline health status
  3. Longer duration of Mechanical Ventilation
  • Pathophysiology
  1. Muscular deconditioning due to prolonged immobilization
  2. Myosin to Actin ratio reduced
  3. Lean Body Mass drops 2% per day with prolonged immobilization
  • Management
  1. Physical Rehabilitation
  2. Graded Exercise program
  3. Jones (2003) Crit Care Med 31(10):2456-61 [PubMed]
  • Course
  1. Complications associated with deconditioning can persist 12 months after ICU admission