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CSF Protein
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CSF Protein
, Cerebrospinal Fluid Protein
See Also
Cerebrospinal Fluid
Cerebrospinal Fluid Examination
Lumbar Puncture
Interpretation
Normal CSF Protein
Normal
Newborn: <150 mg/dl
Adult: 18 to 58 mg/dl
CSF Protein is not related to
Serum Protein
levels
Low
Serum Protein
does not cause low CSF Protein
Interpretation
Correction of Protein for
CSF RBC
Protein rises 1 mg/dl for every 1000
CSF RBC
s
Same tube must be used for protein and CSF
RBC Count
Interpretation
Increased CSF Protein
Diabetes Mellitus
Brain Tumor
Meningioma
Acoustic Neuroma
Ependymoma
Encapsulated
Brain Abscess
Spinal cord tumor
Multiple Sclerosis
Acute purulent
Meningitis
Granuloma
tous
Meningitis
Carcinomatous
Meningitis
Syphilis
(protein may be normal if longstanding)
Guillain-Barre Syndrome
(Infectious polyneuritis)
Protein normal during first few days
Rises after first week
Cushing's Disease
Connective Tissue Disease
Uremia
Myxedema
Cerebral
Hemorrhage
Interpretation
Normal CSF Protein
Brainstem
Glioma
Viral
CNS Infection
s
Multiple Sclerosis
(protein may be mildly elevated)
Ischemic
Cerebrovascular Accident
Interpretation
Decreased CSF Protein
Recent
Lumbar Puncture
Chronic
CSF Leak
age
May be normal if age <2 years
Acute water
Intoxication
References
Kooiker in Roberts (1998) Procedures in ER, p. 1067-75
Ravel (1995) Lab Medicine, Mosby, p. 294-9
Tunkel in Mandell (2000) Infectious Disease, p. 974-8
Seehusen (2003) Am Fam Physician 68:1103-8 [PubMed]
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