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Reactive Airway Dysfunction Syndrome

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Reactive Airway Dysfunction Syndrome, Irritant-induced Asthma

  • Pathophysiology
  1. Type of Work-Related Asthma
    1. Irritant-induced Asthma accounts for 10% of Occupational Asthma cases
    2. Allergic Occupational Asthma (sensitizer IgE mediated immune response) accounts for 90% of cases
  2. Irritants cause direct cell damage and inflammation
    1. Typically caused by a single, high exposure to an irritant
  • Symptoms
  1. Asthma symptoms occur within 24 hours of exposure
  • Causes
  1. 2-DiethylAminoEthanolamine
  2. Acetic Acid
  3. Anhydrous ammonia
  4. Bleaching chemicals
  5. Burning paint fumes
  6. Chlorine gas (e.g. paper mill worker)
  7. Diesel exhaust fumes
  8. Free-based Cocaine
  9. Floor sealant
  10. Hydrochloric acid
  11. Hydrogen sulfide
  12. Inhaled smoke fumes (e.g. firefighters, rescue workers)
  13. Irritant dust (e.g. construction worker, rescue worker)
  14. Phosgene
  15. Phosphoric acid
  16. Silicon
  17. Silo gas
  18. Sodium hydroxide
  19. Sulfuric acid
  20. Tear gas
  21. Toluene diisocyanate
  22. Trichlorosilane
  23. Welding fumes
  24. Zinc chloride