Pharm

Rifapentine

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Rifapentine, Priftin

  • See Also
  • Class
  1. Rifamycin
    1. Inhibits Bacterial RNA polymerase
  • Mechanism
  1. Long-acting Rifampin derivative
  • Contraindications
  1. Children under age 2 years
  2. Latent Tuberculosis with suspected resistance to Isoniazid or Rifampin
  3. HIV patients on Antiretrovirals (due to lower drug levels and risk of resistance)
  4. Unknown safety in pregnancy
  • Dosing
  1. Tuberculosis
    1. Part of multi-drug regimen; high risk of drug resistance Tb if used alone
    2. Rifapentine 600 mg orally twice weekly for 2 months then once weekly for 4 months
  2. Latent Tuberculosis
    1. See Latent Tuberculosis
  • Adverse Effects
  1. See Rifampin
  2. Hyperuricemia
  3. Body secretion discoloration (orange to brown)
    1. Discolors urine and Contact Lenses
  4. Hepatotoxicity (uncommon)
  5. Thrombocytopenia
  6. Neutropenia (rare)
  • Drug Interactions
  1. See Rifampin
  2. Metabolized by Cytochrome P-450 3A3/4
  • Monitoring
  1. Baseline Liver Function Tests and clinical evaluations