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Pyrazinamide

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Pyrazinamide

  • Indications
  • Dosing
  1. Adult: 1.5-2.5 grams PO qd
  2. Pediatric: 15-30 mg/kg/day (Max 2g/day)
  • Adverse Effects
  1. Drug-Induced Hepatitis or Hepatotoxicity
  2. Gastrointestinal upset
  3. Transient Morbiliform Rash
  4. Arthralgias (unrelated to gout)
  5. Hyperuricemia or Acute Gout
  • Monitoring
  1. Baseline
    1. Liver Function Tests
    2. Serum Creatinine
  2. Periodic testing
    1. Liver Function Tests repeated 1-2 times monthly if risks for hepatotoxicity
    2. Serum Uric Acid if symptoms related to gout