Pharm

Pyrazinamide

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Pyrazinamide

  • Dosing
  1. Adult: 1.5-2.5 grams PO qd
  2. Pediatric: 15-30 mg/kg/day (Max 2g/day)
  • Adverse Effects
  1. Hepatotoxicity
  2. Arthralgias
  3. Gastrointestinal upset
  4. Rash
  5. Hyperuricemia
  • Monitoring
  1. Baseline
    1. Liver Function Tests
    2. Serum Creatinine
  2. Periodic testing
    1. Liver Function Tests repeated 1-2 times monthly if risks for hepatotoxicity
    2. Serum Uric Acid if symptoms related to gout