Pharm

Ethambutol

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Ethambutol

  • Background
  1. Drug resistance emerges rapidly
    1. Must be used with other antituberculous drugs
  • Indications
  1. Active Tuberculosis
  • Dosing
  1. Adult: 15-25 mg/kg PO
  2. Pediatric: 15-25mg/kg PO
  • Adverse Effects
  1. Decreased Visual Acuity
  2. Retrobulbar Optic Neuritis
  3. Peripheral Neuropathy
  4. Rash
  • Monitoring
  1. Baseline
    1. Serum Creatinine
      1. Renal Dosing may be needed due to primarily renal clearance
    2. Visual acquity
    3. Color Perception
  2. Monthly retesting
    1. Visual acquity
    2. Color Perception