Lab

Restrictive Lung Disease

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Restrictive Lung Disease, Restrictive Pulmonary Disease, Restrictive Lung Function

  • Causes
  • Medications
  1. Amiodarone
    1. Pulmonary fibrosis
  2. Methotrexate
    1. Pulmonary fibrosis
    2. Hypersensitivity Pneumonitis
  3. Nitrofurantoin
    1. Acute Nitrofurantoin Pulmonary Toxicity
  1. See Pulmonary Function Test
  2. Criteria
    1. FEV1 to FVC Ratio >0.7 (or >LLN or for children>85% of predicted) AND
    2. FVC < LLN (or for age 5 to 18 years old, <80% of predicted)
  3. Assess Severity
    1. FVC over 80%: Normal
    2. FVC over 60%: Mild Restrictive Lung Disease
    3. FVC over 40-50%: Moderate Restrictive Lung Disease
    4. FVC under 50%: Severe Restrictive Lung Disease
  4. Additional testing
    1. Diffusing lung capacity for Carbon Monoxide (DLCO)
    2. DLCO to alveolar volume ratio
    3. Expiratory Reserve Volume
  5. Precaution
    1. Note that mixed obstructive-Restrictive Lung Disease can also occur