STD

Tertiary Syphilis

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Tertiary Syphilis, Syphylitic Gumma, Gumma

  • Pathophysiology
  1. Low-level Syphilis infection with strong immune response
  • Types
  1. Late benign Syphilis (50% of Tertiary Syphilis cases)
    1. Presents with gumma, granulomas and Psoriasis-like Plaques
    2. May form 1 to 10 years after initial infection
    3. Destructive granulomatous lesions (fungating masses) affect any area
    4. Responds rapidly to treatment
  2. Cardiovascular Syphilis
    1. Typically involves Great Vessels (especially ascending aortitis)
    2. Thoracic aneurysm
  3. Neurosyphilis (Occurs in 10% of untreated Syphilis)
    1. Treponemal penetration of the blood brain barrier
    2. Tabes Dorsalis (Peripheral Neuropathy)
    3. Intracranial gummata
    4. Meningitis
    5. Dementia
  • Labs
  • Management
  • Complications
  1. Thoracic Aortic Aneurysm (from ascending aortitis)
  2. Neurosyphilis complications