Pharm

Sulfonamide Allergy

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Sulfonamide Allergy, Sulfa Allergy

  • See Also
  • Pharmacology
  1. Hypersensitivity to Sulfonamide groups most affects Sulfonylarylamines, but can affect Non-Sulfonylarylamines and Sulfonamide Moieties
  2. Sulfonamide Allergy does not cross react with sulfur, sulfate, Sulfites
  • Preparations
  • Sulfonylarylamines (Sulfa agents)
  1. General
    1. Typical sulfa-allergens, with greatest cross-reactivity to other sulfa agents
  2. Sulfa Antibiotics
    1. Trimethoprim-Sulfamethoxazole (Bactrim, Sulfatrim, Co-trimoxazole, Septra)
    2. Sulfadiazine
    3. Sulfacetamide
  3. Sulfa Antiinflammatories
    1. Sulfasalazine
  4. Protease Inhibitors (HIV Infection)
    1. Darunavir (Prezista)
    2. Fosamprenavir (Lexiva)
  • Preparations
  • Non-Sulfonylarylamines
  1. General
    1. Similar structure to Sulfonylarylamines , but hypersensitivity cross-reactivity is uncommon
    2. However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
  2. Diuretics
    1. All Thiazide Diuretics
    2. Some Loop Diuretics (Furosemide, Torsemide, Bumetanide)
  3. Anti-hyperglycemics (Diabetes Mellitus)
    1. Sulfonylureas (e.g. Glipizide)
  4. Analgesics
    1. Celecoxib (Celebrex)
  1. General
    1. Differ significantly from Sulfonylarylamines (despite both having Sulfonamide group)
    2. However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
  2. Neurologic agents
    1. Sumatriptan (Imitrex)
    2. Topiramate (Topamax)
    3. Zonisamide (Zonagran)
  3. Protease Inhibitor (Hepatitis C Infection)
    1. Simeprevir (Olysio)