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Second-Generation Glycopeptide Antibiotic

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Second-Generation Glycopeptide Antibiotic, Semi-Synthetic Glycopeptide Antibiotic, Lipoglycopeptide Antibiotic, Dalbavancin, Dalvance, Oritavancin, Orbactiv

  • Mechanism
  1. Decreases Bacterial cell wall synthesis
  2. Similar coverage and mechanism to Vancomycin
  3. Long-acting agents, with a single parenteral dose covering entire antibiotic course
  • Indications
  1. Refractory Skin and Soft Tissue Infections with failure to respond to maximal oral antibiotic coverage
  • Preparations
  1. Dalbavancin (Dalvance)
    1. Infused over 30 minutes weekly
  2. Oritavancin (Orbactiv)
    1. Infused over 3 hours
    2. Single dose may be sufficient for MRSA Cellulitis
    3. Contraindicated with Warfarin or Heparin use
  • Disadvantages
  1. Expensive ($2500 to $9500 per single dose)
  • References
  1. (2014) Presc Lett 21(8): 43