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Second Generation Broad-spectrum Cephalosporins

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Second Generation Broad-spectrum Cephalosporins, Second Generation Cephalosporins, Cefuroxime, Loracarbef, Cefprozil, Lorabid, Cefzil, Ceftin

  • See Also
  1. Second Generation Anti-anaerobe Cephalosporins
  2. Cephalosporin
  • Coverage
  1. Gram Positive Cocci
  2. EKP Gram Negative Bacteria
  3. Gram Negative Coccobacilli
  • Indications
  1. Respiratory tract infections
  2. Acute Sinusitis
  3. Otitis Media
  4. Community Acquired Pneumonia (esp. Cefuroxime and Cefprozil)
  5. Urinary Tract Infection (esp. Cefuroxime and Cefprozil)
  6. Skin and Soft Tissue Infection (esp. Cefuroxime and Cefprozil)
  • Preparations
  1. Loracarbef (Lorabid)
    1. Adult: 200 to 400 mg po bid
    2. Child
      1. Otitis Media: 30 mg/kg/day divided bid
      2. Other infections: 15 mg/kg/day divided bid
    3. Directions
      1. Take more than 1 hour before or 2 hours after food
  2. Cefprozil (Cefzil)
    1. Adult: 250 to 500 mg orally divided daily to twice daily
    2. Child
      1. Otitis Media: 15 mg/kg/dose orally twice daily
      2. Pharyngitis: 7.5 mg/kg/dose orally twice daily for 10 days
  3. Cefuroxime (Ceftin, Zinacef)
    1. Adult
      1. Parenteral: 750 to 1500 mg IM or IV every 8 hours
      2. Oral: 250 to 500 mg orally twice daily
    2. Child
      1. Parenteral: 50-100 mg/kg/day IV divided every 6-8 hours
      2. Oral: 20-30 mg/kg/day orally divided twice daily
        1. Reported to have unpleasant taste
    3. Directions
      1. Take with food
  4. Cefaclor (Ceclor)
    1. Listed for historical reference only
    2. Risk of significant serum-sickness type reaction