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Second Generation Broad-spectrum Cephalosporins

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Second Generation Broad-spectrum Cephalosporins, Second Generation Cephalosporins, Cefuroxime, Loracarbef, Cefprozil, Lorabid, Cefzil, Ceftin

  • See Also
  1. Second Generation Anti-anaerobe Cephalosporins
  • Coverage
  1. Gram Positive Cocci
  2. EKP Gram Negative Bacteria
  3. Gram Negative Coccobacilli
  • Indications
  1. Respiratory tract infections
  2. Acute Sinusitis
  3. Otitis Media
  • Preparations
  1. Loracarbef (Lorabid)
    1. Adult: 200 to 400 mg po bid
    2. Child
      1. Otitis Media: 30 mg/kg/day divided bid
      2. Other infections: 15 mg/kg/day divided bid
    3. Directions
      1. Take more than 1 hour before or 2 hours after food
  2. Cefprozil (Cefzil)
    1. Adult: 250 to 500 mg PO divided qd to bid
    2. Child
      1. Otitis Media: 15 mg/kg/dose PO bid
      2. Pharyngitis: 7.5 mg/kg/dose PO bid for 10 days
  3. Cefuroxime (Ceftin, Zinacef)
    1. Adult
      1. Parenteral: 750 to 1500 mg IM or IV every 8 hours
      2. Oral: 250 to 500 mg PO bid
    2. Child
      1. Parenteral: 50-100 mg/kg/day IV divided q6-8 hours
      2. Oral: 20-30 mg/kg/day PO divided bid
        1. Reported to have unpleasant taste
    3. Directions
      1. Take with food
  4. Cefaclor (Ceclor)
    1. Listed for historical reference only
    2. Risk of significant serum-sickness type reaction