Pharm

Metronidazole

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Metronidazole, Flagyl

  • Precautions
  1. Carcinogenic in mice and rats (FDA Black box warning)
  • Pharmacokinetics
  1. Half-life: 8 hours
  2. Renal excretion
  • Dosing
  • Children
  1. Dose
    1. Load: Metronidazole 15 mg/kg IV
    2. Maintenance: Metronidazole 7.5 mg/kg/dose
  2. Interval
    1. First week of life: q12 hours
    2. After first week of life: q 8hours
  • Dosing
  • Adult
  1. Intravenous
    1. Loading dose: 15 mg/kg up to 1000 mg IV
    2. Maintenance dose: 7.5 mg/kg up to 500 mg IV q6-8 hour
  2. Oral dose: 250 to 750 mg PO tid
  • Adverse Effects
  1. Antabuse like effect (Never use with Alcohol)
  2. Gastrointestinal intolerance
  3. Neurotoxicity (stop immediately if these occur)
    1. Seizures
    2. Encephalopathy
    3. Cerebellar dysfunction
    4. Peripheral Neuropathy (e.g. distal Paresthesias)
  • Pregnancy
  1. Class B Medication (Avoid in first trimester pregnancy)
  • Directions
  1. Taking with food decreases gastric irritation