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Janus Kinase Inhibitor

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Janus Kinase Inhibitor, Janus Kinase, JAK Inhibitor, Ruxolitinib, Jakafi, Tofacitinib, Xeljanz, Baricitinib, Olumiant, Upadacitinib, Rinvoq

  • See Also
  1. Biologic Agent
  • Mechanism
  1. Interferes with cytokine signalling on receptor binding
  • Preparations
  1. Ruxolitinib or Jakafi (JAK1 and JAK2 Inhibitor)
    1. Indicated in Rheumatoid Arthritis and Myelofibrosis (including Polycythemia Vera)
  2. Tofacitinib or Xeljanz (JAK3 Inhibitor)
    1. Indicated in Rheumatoid Arthritis and Psoriasis
  3. Baricitinib or Olumiant (JAK1 and JAK2 inhibitor)
    1. Indicated in Rheumatoid Arthritis
  4. Upadacitinib or Rinvoq (JAK1 inhibitor)
    1. Indicated in Rheumatoid Arthritis
  • Adverse Effects
  1. Venous Thromboembolism
  2. Sudden cardiovascular death (associated with Tofacitinib)
  3. Immunosuppression
    1. Tuberculosis reactivation risk
    2. Increased risk of Pneumonia, Shingles
  • Precautions
  1. Avoid Live Vaccines
  • References
  1. (2019) Presc Lett 26(10): 58