Pharm

First Generation Cephalosporins

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First Generation Cephalosporins, Cephalexin, Cefazolin, Cefadroxil, Keflex, Duricef, Ancef

  • Indications
  1. Effective alternative to Penicillins
  2. Covers Gram Positive Cocci
  3. Clinical Conditions
    1. Skin and Soft Tissue Infection
    2. Streptococcal Pharyngitis
    3. Not indicated for Otitis Media
  • Mechanism
  • Activity Spectrum
  1. Good Gram Positive Cocci Coverage
    1. Streptococcus
    2. Staphylococcus
  2. Modest EKP Gram Negative Bacteria covered
    1. Escherichia coli
    2. Klebsiella
    3. Proteus
  • Preparations
  • Oral
  1. Directions
    1. May take with or without food
  2. Cephalexin (Keflex)
    1. Adult: 250 to 500 mg PO qid
    2. Child
      1. Otitis Media: 75 to 100 mg/kg/day divided qid
      2. Standard Dose: 25 to 50 mg/kg/day divided qid
  3. Cefadroxil (Duricef)
    1. Adult: 1 to 2 grams/day divided qd to bid
    2. Child: 30 mg/kg/day divided bid
  • Parenteral
  • Cefazolin (Ancef)
  1. Adult: 0.5 to 1.5 grams IM or IV every 6-8 hours
  2. Child
    1. Standard: 25 to 50 mg/kg/day divided q6-8 hours
    2. Severe Infection: 100 mg/kg/day divided q6-8 hours
    3. Maximum: 2 grams per dose