Pharm
First Generation Cephalosporins
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First Generation Cephalosporins
, Cephalexin, Cefazolin, Cefadroxil, Keflex, Duricef, Ancef
Indications
Effective alternative to
Penicillin
s
Covers
Gram Positive Cocci
Clinical Conditions
Skin and Soft Tissue Infection
Streptococcal Pharyngitis
Not indicated for
Otitis Media
Mechanism
Activity Spectrum
Good
Gram Positive Cocci
Coverage
Streptococcus
Staphylococcus
Modest
EKP Gram Negative Bacteria
covered
Escherichia coli
Klebsiella
Proteus
Preparations
Oral
Directions
May take with or without food
Cephalexin (Keflex)
Adult: 250 to 500 mg PO qid
Child
Otitis Media
: 75 to 100 mg/kg/day divided qid
Standard Dose: 25 to 50 mg/kg/day divided qid
Cefadroxil (Duricef)
Adult: 1 to 2 grams/day divided qd to bid
Child: 30 mg/kg/day divided bid
Parenteral
Cefazolin (Ancef)
Adult: 0.5 to 1.5 grams IM or IV every 6-8 hours
Child
Standard: 25 to 50 mg/kg/day divided q6-8 hours
Severe Infection: 100 mg/kg/day divided q6-8 hours
Maximum: 2 grams per dose
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