Pharm
First Generation Cephalosporins
search
First Generation Cephalosporins
, Cefazolin, Cefadroxil, Duricef, Ancef
See Also
Cephalosporin
Cephalexin
(
Keflex
)
Indications
Effective alternative to
Penicillin
s
Covers
Gram Positive Cocci
Covers some
Gram Negative Bacilli
(least coverage of the
Cephalosporin
s)
Clinical Conditions
Skin and Soft Tissue Infection
Streptococcal Pharyngitis
Simple
Urinary Tract Infection
s (
Acute Cystitis
)
Not indicated for
Otitis Media
(inadequate coverage due to resistance)
Mechanism
Activity Spectrum
Good
Gram Positive Cocci
Coverage
Streptococcus
Staphylococcus
Modest
EKP Gram Negative Bacteria
covered
Escherichia coli
Klebsiella
Proteus
Contraindications
Relative
MRSA
Enterococcus
Enterobacter
Proteus
Vulgaris
Morganella
marganii
Pseudomonas
Acinebacter calcoaceticus
Preparations
Oral
Directions
May take with or without food
Cephalexin
(
Keflex
)
Adult: 250 to 500 mg orally 4 times daily
Child: 25 to 50 mg/kg/day divided 4 times daily
Cefadroxil (Duricef)
Adult: 1 to 2 grams/day divided qd to bid
Child: 30 mg/kg/day divided bid
Preparations
Parenteral - Cefazolin (Ancef)
Adult: 0.5 to 1.5 grams IM or IV every 6-8 hours
Child
Standard: 25 to 50 mg/kg/day divided q6-8 hours
Severe Infection: 100 mg/kg/day divided q6-8 hours
Maximum: 2 grams per dose
Resources
Cephalexin
(DailyMed)
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5681d4d2-9b67-4cac-9b94-8368f9978231
Type your search phrase here