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Drug-Induced Fever

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Drug-Induced Fever, Drug Induced Fever, Fever Due to Medications, Drug Fever, Drug-Induced Hyperpyrexia

  • Types
  1. Hypersensitivity Reaction (associated with Eosinophilia, rash)
  2. Idiosyncratic Reaction
  3. Drug-Induced Hyperthemia Syndromes (muscle rigidity and fever >40 C)
    1. Malignant Hyperthermia
    2. Neuroleptic Malignant Syndrome
    3. Serotonin Syndrome
  1. Rigors (53%)
  2. Myalgias (25%)
  3. Leukocytosis (22%)
  4. Eosinophilia (22%)
  5. Rash (18%)
  6. Hypotension (18%)
  • Causes
  • Antimicrobial Induced Fever
  • Causes
  • Anticonvulsant induced fever
  1. Barbiturates
  2. Carbamazepine (Tegretol)
  3. Phenytoin or Dilantin (common)
  • Causes
  • Gastrointestinal Medication induced fever
  1. Cimetidine (Tagemet)
  2. Ranitidine (Zantac)
  3. Phenothiazines
  1. Aspirin
  2. Ibuprofen
  3. Sulindac (Clinoril)
  4. Meperidine (Demerol)
  • Causes
  • Miscellaneous Medications Inducing Fever
  • Management
  1. Withdraw suspected medication causes
    1. Expect fever to resolve within 2-3 days (up to 7 days) of medication discontinuation
  2. Exclude other sources of fever
    1. See Acquired Fever in Hospitalized Patients
    2. See Persistent Fever Causes