Pharm

Cyclic Lipopeptide

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Cyclic Lipopeptide, Lipopeptide, Cubicin, Daptomycin

  • Indications
  1. Methicillin-Resistant Staphylococcus aureus (MRSA)
  2. Complicated Skin Infections
  3. Do not use for Pneumonia
    1. Poorly penetrates lung
    2. Inactivated by surfactant
  • Mechanism
  1. Cyclic Lipopeptide
  2. Depolarizes Bacterial cell membranes
  • Preparations
  1. Intravenous daily dosing
  • Dosing
  1. Adults: 4 mg/kg in NS over 30 minutes once daily
  • Adverse Effects
  1. Muscle toxicity (avoid concurrent Statin use)
  • Monitoring
  1. Obtain serum CPK level weekly while on Daptomycin